University Associate Professor and Honorary Consultant in Paediatric Critical Care
Dr Pathan runs a multi-disciplinary programme of research in Paediatric Critical Illness.
She has expertise in laboratory and translational research and in examining the biology of severe infection.
Her group has interests in immunology, metagenomics, bioinformatics and diagnostics/biomarker research.
Current projects include pathophysiology of severe COVID infection in children, longitudinal analysis of antimicrobial resistance in the PICU setting, infection control therapies and the impact of critical illness on long term quality of life.
The group has received funding from NIHR, Action for Medical Research, the Evelyn Trust and Addenbrooke’s Charitable Trust.
She has written articles on health for the BBC and contributes expert opinion to the media on issues relating to severe illness in children.
Plain English Summary of Research
Dr Nazima Pathan is a clinical researcher in the field of Paediatric Intensive Care.
She is interested in developing ways of personalising the care of critically ill children, to improve the efficiency and safety of interventions to manipulate the body’s response to severe illness and encourage it to revert to normal physiology. Her research group is skilled in profiling patients, and their body compartments during the process of critical illness to develop predictive markers of organ dysfunction and outcomes in children who are admitted to the Paediatric Intensive Care Unit.
Key Publications – full list available via Pubmed
1. Hide and seek in a pandemic: review of SARS-CoV-2 infection and sequelae in children, J.A. Clark, Pathan, N., Exp Physiol 2021 (in press)
2. Healthcare-associated bacterial infections in the paediatric ICU Akinkugbe, O., Cooke, F., Pathan, N. J Antimicrob Resist 2020 Sep 14;2(3):dlaa066. doi: 10.1093/jacamr/dlaa066.eCollection 2020 Sep.
3. Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. RECOVERY Collaborative Group. Lancet 2021 May 29;397(10289):2049-2059. doi: 10.1016/S0140-6736(21)00897-7.Epub 2021 May 14.
4. Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial RECOVERY Collaborative Group. Lancet, 2021 May 1;397(10285):1637-1645.doi: 10.1016/S0140-6736(21)00676-0
5. Optimal outcome measures for a trial of not routinely measuring gastric residual volume in neonatal care: a mixed methods consensus process. Gale, C., Dorling, J., Arch, B., Woolfall, K., Deja, E., Roper, L., Jones, A., Latten, L., Eccleson, H., Hickey, H., Pathan, N., Preston, J., Beissel, A., Andrzejerska, I., Valla, F., Tume, L. Arch Dis Child Fetal Neonatal Ed 2021 May;106(3):292-297.
6. Can they stomach it? Parent and practitioner acceptability of a trial comparing gastric residual volume measurement versus no gastric residual volume in UK NNU and PICUs: a feasibility study Deja, E., Roper, L., Tume, L., Dorling, J., Gale, C., Arch, B., Latten, L., Pathan, N., Eccleson, H., Hickey, H., Preston, J., Beissel, A., Andrzejerska, I., Valla, F., Woolfall, K. Pilot Feasibility Studies 2021 Feb 16;7(1):49. doi: 10.1186/s40814-021-00784-5.
7. Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. RECOVERY Collaborative Group.Lancet. 2021 Feb 13;397(10274):605-612.
8. A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process. Harwood R, Allin B, Jones CE, Whittaker E …PIMS-TS National Consensus Management Study Group.Lancet Child Adolesc Health. 2021 Feb;5(2):133-141. doi: 10.1016/S2352-4642(20)30304-7. Epub 2020 Sep 18.
9. Relationship between inflammation and metabolic regulation of energy expenditure by GLP-1 in critically ill children. Zaher S, Branco R, Meyer R, White D, Ridout J, Pathan N.Clin Nutr. 2021 Feb;40(2):632-637.
10. Routine gastric residual volume measurement to guide enteral feeding in mechanically ventilated infants and children: the GASTRIC feasibility study. Tume LN, Woolfall K, Arch B, Roper L, Deja E, Jones AP, Latten L, Pathan N, Eccleson H, Hickey H, Parslow R, Preston J, Beissel A, Andrzejewska I, Gale C, Valla FV, Dorling J.Health Technol Assess. 2020 May;24(23):1-120.
11. Tume L. et al., Determining Optimal Outcome Measures in a Trial Investigating No Routine Gastric Residual Volume Measurement in Critically Ill Children. JPEN J Parenter Enteral Nutr. 2020 Mar 6. doi: 10.1002/jpen.1817.
12. Tume L. et al., Nutritional support for children during critical illness: European Society of Pediatric and Neonatal Intensive Care (ESPNIC) metabolism, endocrine and nutrition section position statement and clinical recommendations. Intensive Care Med. 2020 Mar;46(3):411-425. doi: 10.1007/s00134-019-05922-5. Epub 2020 Feb 20.
13. Wijeyesekera, A., et al Multi-Compartment Profiling of Bacterial and Host Metabolites Identifies Intestinal Dysbiosis and Its Functional Consequences in the Critically Ill Child. Critical Care Med 2019, Jun 4
14. Pulham, R.A., et al; Feasibility and Acceptability of Methods to Collect Follow-Up Information From Parents 12 Months After Their Child’s Emergency Admission to Pediatric Intensive Care. Pediatr Crit Care Med. 2019. Apr 20(4):e199-e207
15. FeinsteinY., et al; Cohort profile of the Biomarkers of Acute Serious Illness in Children (BASIC) study: a prospective multicentre cohort study in critically ill children. BMJ Open. 2018 Nov 8;8 (11): e024729
16. Tume, L., et al Priorities for Nutrition Research in Paediatric Critical Care JPEN 2018 Dec 26
17. Zaher, S., et al Association between enteral macronutrient delivery and inflammatory response in critically ill children. Clin Nutr 2018 Oct 11 pii: S0261-5614(18)32471-3.
18. Pathan, N. Enteral Feeding of Infants Undergoing Congenital Heart Surgery: Consensus Needed! Pediatr Crit Care Med. 2018 Feb;19(2):169-170.
19. Murthy S, Pathan N, Cuthbertson BH. Selective digestive decontamination in critically ill children: A survey of Canadian providers. J Crit Care. 2017 Jun;39:169-171
20. Valla F., et al. Thigh ultrasound monitoring identifies decreases in quadriceps femoris thickness as a frequent observation in critically ill children. Pediatric Critical Care Medicine. 2017 Aug;18(8):e339-e347.
21. Martinón-Torres F, Png E, Khor CC, Davila S, Wright VJ, Sim KS, et al. Natural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide association studies. Sci Rep. 2016;6:35842
22. Herberg JA, Kaforou M, Wright VJ, Shailes H, et al. Diagnostic Test Accuracy of a 2-Transcript Host RNA Signature for Discriminating Bacterial vs Viral Infection in Febrile Children. JAMA. 2016 Aug 23-30;316(8):835-45.
23. Ray S, Cvetkovic M, Brierley J, Lutman DH, Pathan N, Ramnarayan P, et al. Shock Index Values and Trends in Pediatric Sepsis: Predictors or Therapeutic Targets? A Retrospective Observational Study. Shock. 2016;46(3).
24. Ray S, Cvetkovic M, Lutman DH, Pathan N, Ramnarayan P, Inwald DP, et al. Real-life use of vasopressors and inotropes in cardiogenic shock-observation is necessarily “theory-laden.” Crit Care. 2016;20(1).
25. Iliopoulos I, Branco RG, Brinkhuis N, Furck A, Larovere J, Cooper DS, et al. Mesenteric near-infrared spectroscopy and risk of gastrointestinal complications in infants undergoing surgery for congenital heart disease. Cardiol Young. 2016;26(4)..
26. Marino LV, Pathan N, Meyer RW, Wright VJ, Habibi P. An in vitro model to consider the effect of 2 mM glutamine and KNK437 on endotoxin-stimulated release of heat shock protein 70 and inflammatory mediators. Nutrition. 2016;32(3).
27. Correia GDS, Wooi Ng K, Wijeyesekera A, Gala-Peralta S, Williams R, Maccarthy-Morrogh S, et al. Metabolic profiling of children undergoing surgery for congenital heart disease. Crit Care Med. 2015;43(7).