University Lecturer and Honorary Consultant in Paediatric Critical Care
Dr Pathan qualified in Medicine from the University of London (St Bartholomew’s Hospital Medical School). She completed her postgraduate medical training in London, Oxford and Duke Children’s Hospital in North Carolina, USA.
She then undertook a clinical research fellow position in Paediatric Intensive Care at Imperial College London, where she investigated the pathophysiology of myocardial dysfunction in septic shock. She received her specialist training in Paediatric Critical Care in London, obtaining her CCT in Paediatrics and Paediatric Intensive Care. She undertook a clinical academic within the Paediatric Intensive Care Unit at the Royal Brompton and Harefield Hospital, London alongside a HEFCE Clinical Senior Lecturer position at Imperial College London.
In 2013, she was appointed University Lecturer and Honorary Consultant in Paediatric Intensive Care at the University of Cambridge.
Critical illness involves complex, dynamic changes in host physiology. Intensive care supports organ function through the period of acute disease. Increasingly though, critical care clinicians are realising that recovery and rehabilitation could be optimised using a personalised approach, possibly modulating the host reponse to critical illness and restore normal homeostasis.
Dr Pathan’s research team is focused on methods to improve personalised medicine and biomarker identification/ validation in Paediatric critical illness. Her research has clinical and translational elements, and she has a multidisciplinary research team, which includes clinicians, scientists, nurses and dietitians.
Current research themes include infection, inflammation, metabolism, nutrition and host-microbiome relationships in critical illness.
The group’s work includes studies examining novel diagnostic methods for severe infection, antimicrobial resistance and biomarkers for severe organ failure in critically ill children.
Plain English Summary of Research
Dr Nazima Pathan is a clinical researcher in the field of Paediatric Intensive Care.
She is interested in developing ways of personalising the care of critically ill children, to improve the efficiency and safety of interventions to manipulate the body’s response to severe illness and encourage it to revert to normal physiology. Her research group is skilled in profiling patients, and their body compartments during the process of critical illness to develop predictive markers of organ dysfunction and outcomes in children who are admitted to the Paediatric Intensive Care Unit.
Key Publications – full list available via Pubmed
1: Martinón-Torres F, et al.
Natural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide
association studies. Sci Rep. 2016 Nov 2;6:35842.
2: Ray S, et al
Real-life use of vasopressors and inotropes in cardiogenic shock-observation is
necessarily ‘theory-laden’. Crit Care. 2016 Sep 26;20(1):293.
3: Herberg JA, et al
Diagnostic Test Accuracy of a 2-Transcript Host RNA Signature for Discriminating Bacterial vs
Viral Infection in Febrile Children. JAMA. 2016 Aug 23-30;316(8):835-45.
4: Ray S, Cvetkovic M, Brierley J, Lutman DH, Pathan N, Ramnarayan P, Inwald DP,
Peters MJ. Shock Index Values and Trends in Pediatric Sepsis: Predictors or
Therapeutic Targets? A Retrospective Observational Study. Shock. 2016 May 19.[Epub ahead of print] PubMed PMID: 27206274.
5: Iliopoulos I, Branco RG, Brinkhuis N, Furck A, LaRovere J, Cooper DS, Pathan
Mesenteric near-infrared spectroscopy and risk of gastrointestinal
complications in infants undergoing surgery for congenital heart disease. Cardiol
Young. 2016 Apr;26(4):772-80. doi: 10.1017/S1047951115001365. Epub 2015 Sep 7.
PubMed PMID: 26343176.
6: Marino LV, Pathan N, Meyer RW, Wright VJ, Habibi P. An in vitro model to
consider the effect of 2 mM glutamine and KNK437 on endotoxin-stimulated release
of heat shock protein 70 and inflammatory mediators. Nutrition. 2016
Mar;32(3):375-83. doi: 10.1016/j.nut.2015.09.007. Epub 2015 Sep 30. PubMed PMID:
7: Marino LV, Pathan N, Meyer R, Wright VJ, Habibi P. The effect of 2 mMol
glutamine supplementation on HSP70 and TNF-α release by LPS stimulated blood from
healthy children. Clin Nutr. 2015 Dec;34(6):1195-201. doi:
10.1016/j.clnu.2014.12.009. Epub 2014 Dec 23. PubMed PMID: 25556350.
8: Correia GD, Wooi Ng K, Wijeyesekera A, Gala-Peralta S, Williams R,
MacCarthy-Morrogh S, Jiménez B, Inwald D, Macrae D, Frost G, Holmes E, Pathan N.
Metabolic Profiling of Children Undergoing Surgery for Congenital Heart Disease.
Crit Care Med. 2015 Jul;43(7):1467-76. doi: 10.1097/CCM.0000000000000982. PubMed
PMID: 25844698; PubMed Central PMCID: PMC4467581.
9: Mitting R, Marino L, Macrae D, Shastri N, Meyer R, Pathan N. Nutritional
status and clinical outcome in postterm neonates undergoing surgery for
congenital heart disease. Pediatr Crit Care Med. 2015 Jun;16(5):448-52. doi:
10.1097/PCC.0000000000000402. PubMed PMID: 25828781.
10: Cvetkovic M, Lutman D, Ramnarayan P, Pathan N, Inwald DP, Peters MJ. Timing of
death in children referred for intensive care with severe sepsis: implications
for interventional studies. Pediatr Crit Care Med. 2015 Jun;16(5):410-7. doi:
10.1097/PCC.0000000000000385. PubMed PMID: 25739013.
11: Marino LV, Pathan N, Meyer R, Wright V, Habibi P. Glutamine depletion and heat
shock protein 70 (HSP70) in children with meningococcal disease. Clin Nutr. 2014
Oct;33(5):915-21. doi: 10.1016/j.clnu.2013.09.013. Epub 2013 Oct 9. PubMed PMID:
12: Meyer R, Kulinskaya E, Briassoulis G, Taylor RM, Cooper M, Pathan N, Habibi P.
The challenge of developing a new predictive formula to estimate energy
requirements in ventilated critically ill children. Nutr Clin Pract. 2012
Oct;27(5):669-76. doi: 10.1177/0884533612448479. Epub 2012 Jun 7. PubMed PMID:
13: Ng KW, Allen ML, Desai A, Macrae D, Pathan N. Cardioprotective effects of
insulin: how intensive insulin therapy may benefit cardiac surgery patients.
Circulation. 2012 Feb 7;125(5):721-8. doi: 10.1161/CIRCULATIONAHA.111.063784.
Review. PubMed PMID: 22311884.
14: Pathan N, Burmester M, Adamovic T, Berk M, Ng KW, Betts H, Macrae D, Waddell
S, Paul-Clark M, Nuamah R, Mein C, Levin M, Montana G, Mitchell JA. Intestinal
injury and endotoxemia in children undergoing surgery for congenital heart
disease. Am J Respir Crit Care Med. 2011 Dec 1;184(11):1261-9. doi:
10.1164/rccm.201104-0715OC. Epub 2011 Aug 25. PubMed PMID: 21868501.
15: Pathan N, Franklin JL, Eleftherohorinou H, Wright VJ, Hemingway CA, Waddell
SJ, Griffiths M, Dennis JL, Relman DA, Harding SE, Levin M. Myocardial depressant
effects of interleukin 6 in meningococcal sepsis are regulated by p38
mitogen-activated protein kinase. Crit Care Med. 2011 Jul;39(7):1692-711. doi:
10.1097/CCM.0b013e3182186d27. PubMed PMID: 21494108.
16: De Wit B, Meyer R, Desai A, Macrae D, Pathan N. Challenge of predicting
resting energy expenditure in children undergoing surgery for congenital heart
disease. Pediatr Crit Care Med. 2010 Jul;11(4):496-501. doi:
10.1097/PCC.0b013e3181ce7465. PubMed PMID: 20124946.
17: Allen ML, Pathan N. Steroids in cardiac surgery: right time, right dose,
right patient group. Crit Care Med. 2009 May;37(5):1815. doi:
10.1097/CCM.0b013e3181a09521. PubMed PMID: 19373058.
18: Allen M, Sundararajan S, Pathan N, Burmester M, Macrae D. Anti-inflammatory
modalities: their current use in pediatric cardiac surgery in the United Kingdom
and Ireland. Pediatr Crit Care Med. 2009 May;10(3):341-5. doi:
10.1097/PCC.0b013e3181a3105d. PubMed PMID: 19325509.
19: Pathan N, Ridout DA, Smith E, Goldman AP, Brown KL. Predictors of outcome for
children requiring respiratory extra-corporeal life support: implications for
inclusion and exclusion criteria. Intensive Care Med. 2008 Dec;34(12):2256-63.
doi: 10.1007/s00134-008-1232-3. Epub 2008 Aug 1. PubMed PMID: 18670760.
20: Pathan N, Williams EJ, Oragui EE, Stephens AC, Levin M. Changes in the
interleukin-6/soluble interleukin-6 receptor axis in meningococcal septic shock.
Crit Care Med. 2005 Aug;33(8):1839-44. PubMed PMID: 16096463.
21: Pathan N, Hemingway CA, Alizadeh AA, Stephens AC, Boldrick JC, Oragui EE,
McCabe C, Welch SB, Whitney A, O’Gara P, Nadel S, Relman DA, Harding SE, Levin M.
Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock.
Lancet. 2004 Jan 17;363(9404):203-9. PubMed PMID: 14738793.