Alexander Ross
MBBS BSc (Hons)
Academic Clinical Fellow
E-mail: ar762@cam.ac.uk
Research interest:
Exploring the epigenetics of the intestinal immune system in health and disease, particularly inflammatory bowel disease (IBD).
Use of the human intestinal organoid model to investigate responses to infection and inflammation in patients with IBD.
Key words/Topics:
Epigenetics, Inflammatory Bowel Disease, Paediatrics, DNA methylation, mucosal immunology, intestinal innate immunity, intestinal organoid.
Key Publications
Kraiczy J, Nayak KM, Howell KJ, Ross A, Forbester J, Salvestrini C, Mustata R, Perkins S, Andersson-Rolf A, Leenen E, Liebert A, Vallier L, Rosenstiel P, Stegle O, Dougan G, Heuschkel R, Koo BK & Zilbauer M. 2017. DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development. GUT: In press. doi: 10.1136/gutjnl -2017-314817
Howell KJ, Kraiczy J, Nayak KM, Gasparetto M, Ross A, Lee C, Mak TN, Koo BK, Kumar N, Lawley T, Sinha A, Rosenstiel P, Heuschkel R, Stegle O, Zilbauer M. 2017. DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome. Gastroenterology pii: S0016-5085(17)36241-8. doi: 10.1053/j.gastro.2017.10.007. [Epub ahead of print]
Kraiczy J, Nayak K, Ross A, Raine T, Mak TN, Gasparetto M, Cario E, Rakyan V, Heuschkel R and Zilbauer M. 2016. Assessing DNA methylation in the developing human intestinal epithelium: potential link to inflammatory bowel disease. Mucosal Immunology 9: 647–658; doi:10.1038/mi.2015.88
Ross A, Shelley H, Novell K, Ingham E, Callan J, Heuschkel R, Morris MA, Zilbauer M. Assessing quality outcome measures in children with coeliac disease-experience from two UK centres. Nutrients, 2013. 5(11), pp.4605–4613
Atherton R, Ross A, Jessop F, Williams R, Heuschkel R, Zilbauer M. Coeliac Disease in Children with Type 1 Diabetes: Are Current Guidelines Proving Difficult to Implement in Practice? JPGN, 2014. 54(1), pp.136–160.