Felicity Payne

BSc (Hons)

Bioinformatician

E-mail: fp215@cam.ac.uk

 

Research interest:

Our research theme is focused on epigenetics of the intestinal immune system in health and disease.  Specifically, we are currently exploring the integration of genome wide/whole genome profiling approaches to a large, prospectively recruited human tissue sample collection, in order to investigate disease pathogenesis as well as develop clinical biomarkers for patients suffering from Inflammatory Bowel Diseases (IBD).

Collaborators

Dr Paul Lyons

Key words/Topics

Epigenetics, Inflammatory Bowel Disease, Paediatrics, DNA methylation, mucosal immunology, intestinal innate immunity.

Key Publications

Lotta LA, Gulati P, Day FR, Payne F, Ongen H, van d Bunt M, Gaulton KJ, Eicher JD, Sharp SJ, Luan J, De Lucia Rolfe E, Stewart ID, Wheeler E, Willems SM, Adams C, Yaghootkar H, EPIC-InterAct Consortium; Cambridge FPLD1 Consortium, Forouhi NG, Khaw KT, Johnson AD, Semple RK, Frayling T, Perry JR, Dermitzakis E, McCarthy MI, Barroso I*, Wareham NJ*, Savage DB*, Langenberg C*, O’Rahilly S*, Scott RA*.  Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.  Nat Genet (2017).  49(1): 17-26

The UK10K Consortium.  The UK10K project identifies rare variants in health and disease.  Nature (2015).  526(7571): 82-90

Payne F*, Colnaghi R*, Rocha N*, Seth A*, Harris J, Carpenter G, Bottomley WE, Wheeler E, Wong S, Saudek V, Savage DB, O’Rahilly S, Carel JC*, Barroso I*, O’Driscoll M*, Semple R*.  Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance.  J Clin Invest (2014).  124(9): 4028-38

Payne F*, Lim K*, Girousse A*, Brown RJ, Kory N, Robbins A, Xue Y, Sleigh A, Cochran E, Adams C, Dev Borman A, Russel-Jones D, Gorden P, Semple RK, Saudek V, O’Rahilly S, Walther TC, Barroso I*, Savage DB*.  Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease.  Proc Natl Acad Sci US (2014).  111(24): 8901-6

Payne F, Cooper JD, Walker NM, Lam AC, Smink LJ, Nutland S, Stevens HE, Hutchings J, Todd JA.  Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes.  J Leukoc Biol (2007).  81(3)

Payne F*, Smyth DJ*, Pask R, Cooper JD, Masters J, Wang WY, Godfrey LM, Bowden G, Szeszko J, Smink LJ, Lam AC, Burren O, Walker NM, Nutland S, Rance H, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîrgovişte C, Todd JA, Twells RC.  No evidence for association of the TATA-box binding protein glutamine repeat sequence of the flanking chromosome 6q27 region with type 1 diabetes.  Biochem Biophys Res Commun (2005).. 331(2):435-41

Payne F*, Smyth DJ*, Pask R, Barratt BJ, Cooper JD, Twells RC, Walker NM, Lam AC, Smink LJ, Nutland S, Rance HE, Todd JA.. Haplotype tag single nucleotide polymorphism analysis of the human orthologues of the rat type 1 diabetes genes Ian4 (Lyp/Iddm1) and Cblb.  Diabetes (2004).  53(2):505-9