Consultant Paediatric Haematologist and Associate Lecturer University of Cambridge
CRN Eastern Children’s Cancer and Leukaemia Subspecialty Lead
RCPCH representative on the UK National Transfusion Committee
SHOT (Serious Hazards of Transfusion) Working Expert Group
Member UK National Commissioning Group for Blood
Member UKHCDO Haemophilia Prophylaxis Task Force

I am a Consultant Paediatric Haematologist with a wide clinical practice in both malignant and non-malignant haematology with a sub-speciality interest in supportive care (particularly transfusion) and the interaction between coagulation and malignancy.

 

Key publications:

Science. 2019 Wei et al ( including Kelly A.M. as collaborator) May 24;364(6442) doi: 10.1126/science.aau6520. 23. Germline selection shapes human mitochondrial DNA diversity.

Blood. 2017 Kelly A.M., Garner S.F., Foukaneli T., et al. The effect of variation in donor platelet function on transfusion outcome: a semi-randomised, double blind, controlled trial.

Am J Hematol. 2017 Bazin J, Karnik L, Tudor-Williams G, Kelly A.M, Bain B. Dec;92(12):1391-1392. doi: 10.1002/ajh.24815. Juvenile myelomonocytic leukemia in an infant with congenital human immunodeficiency virus and cytomegalovirus infection.

Blood. 2017 Sivapalaratnam S, et al (including Kelly A.M.). Jan 26;129(4):520-524. doi: 10.1182/blood-2016-08-732248. Rare variants in GP1BB are responsible for autosomal dominant macrothrombocytopenia.

Vox Sang. 2017.Garner S.F., Furnell A., Kahan B.C., Jones C.I., Attwood A., Harrison P., Kelly A.M., Goodall A.H., Cardigan R., Ouwehand W.H. Jan;112(1):18-24. doi: 10.1111/vox.12468..Platelet responses to agonists in a cohort of highly characterised platelet donors are consistent over time.

Blood. 2016 Simeoni I et al (including Kelly A.M.).Jun 9;127(23):2791-803. doi: 10.1182/blood-2015-12-688267. Epub 2016 Apr 15.A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders.

Sci Transl Med. 2016 Turro E et al (including Kelly A.M.). Mar 2;8(328):328ra30. doi: 10.1126/scitranslmed.aad7666. A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.

Blood. 2016 Stritt S et al (including Kelly A.M.). Jun 9;127(23):2903-14. doi: 10.1182/blood-2015-10-675629. A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss.

Neonatology 2015. Carr, R., Kelly, A. M. & Williamson, L. M. 107, 1-7, doi:10.1159/000365163. Neonatal thrombocytopenia and platelet transfusion – a UK perspective..

Genome medicine  2015 7, 36, doi:10.1186/s13073-015-0151-5. Westbury, S. K., Turro, E., Greene, D., Lentaigne, C., et al. (including Kelly A.M.)  Human phenotype ontology annotation and cluster analysis to unravel genetic defects in 707 cases with unexplained bleeding and platelet disorders.

Science 2014. Chen, L., Kostadima, M., Martens, J. H., et al. (including Kelly A.M.) 345, 1251033, doi:10.1126/science.1251033 (2014). Transcriptional diversity during lineage commitment of human blood progenitors.

Transfusion 2014. Estcourt, L. J., Pinchon, D., Symington, E., Kelly, A. M., Doree, C., Brunskill, S., Glidewell, L. & Stanworth, S. 54, 1166-1179, doi:10.1111/trf.12441 (2014).Does bleeding affect patient-reported outcome measures in patients with myelodysplasia or hematologic malignancies: a systematic review.

Nucleic acids research 2014 42, D966-974, doi:10.1093/nar/gkt1026.Kohler, S., Doelken, S. C., Mungall, C. J., et al. (including Kelly A.M.) The Human Phenotype Ontology project: linking molecular biology and disease through phenotype data.

Early human development 2013. Kelly, A. M. & Williamson, L. M. 89, 855-860, doi:10.1016/j.earlhumdev.2013.08.025. Neonatal transfusion..

British journal of haematology 2011. Hart, D., Sayer, R., Miller, R., Edwards, S., Kelly, A., Baglin, T., Hunt, B., Benjamin, S., Patel, R., Machin, S. & Scully, M. 153, 515-519, doi:10.1111/j.1365-2141.2011.08636.x. Human immunodeficiency virus associated thrombotic thrombocytopenic purpura–favourable outcome with plasma exchange and prompt initiation of highly active antiretroviral therapy.

 

Text book chapter:

Kelly A.M.,  Stanworth S., New H. Neonatal and Paediatric Component Therapy. Chapter in Haematology in Critical Care. Blackwell (2014).