MSc, BSc (Hons)
Our research theme is focused on epigenetics of the intestinal immune system in health and disease particularly inflammatory bowel disease (IBD). Specifically, we are currently exploring the impact of epigenetic mechanisms such as DNA methylation and histone modifications on regulating gene expression in purified cell subsets such as the intestinal epithelium as well as peripheral blood mononuclear cells (PBMCs).
Epigenetics, Inflammatory Bowel Disease, Paediatrics, DNA methylation, mucosal immunology, intestinal innate immunity.
- Kraiczy J, Nayak KM, Howell KJ, Ross A, Forbester J, Salvestrini C, Mustata R, Perkins S, Andersson-Rolf A, Leenen E, Liebert A, Vallier L, Rosenstiel P, Stegle O, Dougan G, Heuschkel R, Koo BK & Zilbauer M. 2017. DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development. GUT: In press. doi: 10.1136/gutjnl -2017-314817
- Howell KJ, Kraiczy J, Nayak KM, Gasparetto M, Ross A, Lee C, Mak TN, Koo BK, Kumar N, Lawley T, Sinha A, Rosenstiel P, Heuschkel R, Stegle O, Zilbauer M. 2017. DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome. Gastroenterology pii: S0016-5085(17)36241-8. doi: 10.1053/j.gastro.2017.10.007. [Epub ahead of print]
- Kraiczy J, Nayak KM, Ross A, Raine T, Mak TN, Gasparetto M, Cario E, Rakyan V, Heuschkel R and Zilbauer M. 2016. Assessing DNA methylation in the developing human intestinal epithelium: potential link to inflammatory bowel disease. Mucosal Immunology 9: 647–658; doi:10.1038/mi.2015.88
- Jenke AC, Postberg J, Raine T, Nayak KM, Molitor M, Wirth S, Kaser A , Parkes M , Heuschkel RB , Orth V, Zilbauer M . DNA methylation analysis in the inestinal epithelium-effect of cell separation on gene expression and methylation profile PLoS One.  2013;8(2):e55636. doi:10.1371/journal.pone.0055636. Epub 2013 Feb 8.