BA PhD MB BChir
Academic Clinical Fellow in Paediatrics
My research interests focus on epigenetic plasticity in the context of normal development and in paediatric disease. Epigenetic marks are chemical modifications attached to DNA or the proteins around which DNA is wound which alter how genes are expressed. Epigenetic marks are inherited when a cell divides and can result in lasting changes in a cell’s identity and function without changing the underlying genetic sequence. Small epigenetic changes at even a single region of the genome can have a devastating effect on a child’s health and development – for example, Prader-Willi, Beckwith-Wiedemann and Angelman Syndromes can all be caused by highly localised epigenetic changes. The environment has a huge impact on health across the life-course. An organism will respond to an environmental challenge by changing gene expression, and this is controlled through epigenetic processes. Understanding these processes and how they are modulated by the environment will allow us to develop new treatments for a wide variety of conditions. Crucially, unlike genetic changes, epigenetic marks are reversible, and therefore offer enormous therapeutic potential. This is particularly true in paediatric medicine, where an altered early life environment due to prematurity or in utero compromise is one of the most significant threats globally to child health.
Intergenerational epigenetic inheritance and metabolic disease
A personalised model of the gut epigenome and microbiome in paediatric inflammatory bowel disease
Collaborators outside this directory
- Professor Anne Ferguson-Smith
- Dr Mary-Elizabeth Patti
- Professor Andrew Prentice
- Transgenerational epigenetic inheritance
- Metabolic disease
- Radford EJ, Ito M, Shi H, Corish JA, Yamazawa K, Isganaitis E, Seisenberger S, Hore TA, Reik W, Erkek S, Peters AH, Patti ME, Ferguson-Smith AC. In utero undernourishment perturbs the adult sperm methylome, and is linked to metabolic disease transmission. PMID: 25011554 Science 2014 Aug 15;345(6198)
- Radford EJ, Isganaitis E, Jimenez-Chillaron J, Schroeder J, Molla M, Andrews S, Didier N, Charalambous M, McEwen K, Marazzi G, Sassoon D, Patti ME, Ferguson-Smith AC. An unbiased assessment of the role of imprinted genes in an intergenerational model of developmental programming. PMID: 22511876 PLoS Genetics 2012;8(4):e1002605.
- Ferron SR, Charalambous M*, Radford E*, McEwen K, Wildner H, Hind E, Morante-Redolat JM, Laborda J, Guillemot F, Bauer SR, Fariñas I, Ferguson-Smith AC. Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis. PMID: 21776083 Nature 2011 Jul 20;475(7356):381-5.*joint authorship.
- Ferron SR, Radford EJ, Domingo-Muelas A, Kleine I, Ramme A, Gray D, Sandovici I, Constancia M, Ward A, Menheniott TR, Ferguson-Smith AC. Differential genomic imprinting regulates paracrine and autocrine roles of IGF2 in mouse adult neurogenesis. PMID: 26369386 Nature Communications 2015 Sep 15;6:8265
- Radford EJ, Ferguson-Smith AC: Are you what your grandmother ate? Exploring the nature and scope of epigenetic inheritance. Nature Reviews Endocrinology, in preparation.
- Radford EJ, Ferrón SR, Ferguson-Smith AC. Genomic imprinting as an adaptive model of developmental plasticity FEBS Letters 2011 Jul 7;585(13):2059-66